The cognitive effects of adjuvant chemotherapy in early stage breast cancer: a prospective study
Identifieur interne : 002260 ( Main/Exploration ); précédent : 002259; suivant : 002261The cognitive effects of adjuvant chemotherapy in early stage breast cancer: a prospective study
Auteurs : Angela Stewart [Canada] ; Barbara Collins [Canada] ; Joyce Mackenzie [Canada] ; Eva Tomiak [Canada] ; Shailendra Verma [Canada] ; Catherine Bielajew [Canada]Source :
- Psycho‐Oncology [ 1057-9249 ] ; 2008-02.
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Abstract
Purpose: The primary purpose of this study was to evaluate the cognitive effects of adjuvant chemotherapy in post‐menopausal breast cancer patients. Patients and methods: Breast cancer patients scheduled to receive adjuvant chemotherapy (n = 61) completed comprehensive cognitive testing before and after treatment. A control group of women receiving adjuvant hormonal therapy (n = 51) was tested at comparable intervals. Results: Mean scores for both patient groups were within the normal range relative to published norms on all cognitive tests at both time points, and generally inclined or stayed the same from baseline to retest in both groups. However, in an analysis of individual change scores, the chemotherapy patients were 3.3 times more likely than the hormonal patients to show reliable cognitive decline (31 and 12%, respectively). Chemotherapy subjects showing decline were less educated and had higher baseline depression scores than their counterparts who did not decline. Working memory was the cognitive domain most vulnerable to the effects of chemotherapy. Conclusion: These data support previous findings of a subtle negative influence of chemotherapy on cognitive function in a subgroup of breast cancer patients. The results are discussed in terms of the importance of study design. Copyright © 2007 John Wiley & Sons, Ltd.
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DOI: 10.1002/pon.1210
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wicri:level="1"><country>Canada</country><wicri:regionArea>The Ottawa Hospital, Civic Campus, 1053 Carling Ave, Room A603, Ottawa, Ont.</wicri:regionArea><wicri:noRegion>Ont.</wicri:noRegion></affiliation></author><author><name sortKey="Mackenzie, Joyce" sort="Mackenzie, Joyce" uniqKey="Mackenzie J" first="Joyce" last="Mackenzie">Joyce Mackenzie</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>The Ottawa Hospital, Civic Campus, Ottawa, Ont.</wicri:regionArea><wicri:noRegion>Ont.</wicri:noRegion></affiliation></author><author><name sortKey="Tomiak, Eva" sort="Tomiak, Eva" uniqKey="Tomiak E" first="Eva" last="Tomiak">Eva Tomiak</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ont.</wicri:regionArea><wicri:noRegion>Ont.</wicri:noRegion></affiliation></author><author><name sortKey="Verma, Shailendra" sort="Verma, Shailendra" 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Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2008-02">2008-02</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="122">122</biblScope><biblScope unit="page" to="130">130</biblScope></imprint><idno type="ISSN">1057-9249</idno></series><idno type="istex">EC7A36E1EC464149EF55AF24DD86EAC3DB1E293B</idno><idno type="DOI">10.1002/pon.1210</idno><idno type="ArticleID">PON1210</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1057-9249</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>adjuvant chemotherapy</term><term>adjuvant hormonal treatment</term><term>breast cancer</term><term>cognitive function</term><term>oncology</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purpose: The primary purpose of this study was to evaluate the cognitive effects of adjuvant chemotherapy in post‐menopausal breast cancer patients. Patients and methods: Breast cancer patients scheduled to receive adjuvant chemotherapy (n = 61) completed comprehensive cognitive testing before and after treatment. A control group of women receiving adjuvant hormonal therapy (n = 51) was tested at comparable intervals. Results: Mean scores for both patient groups were within the normal range relative to published norms on all cognitive tests at both time points, and generally inclined or stayed the same from baseline to retest in both groups. However, in an analysis of individual change scores, the chemotherapy patients were 3.3 times more likely than the hormonal patients to show reliable cognitive decline (31 and 12%, respectively). Chemotherapy subjects showing decline were less educated and had higher baseline depression scores than their counterparts who did not decline. Working memory was the cognitive domain most vulnerable to the effects of chemotherapy. Conclusion: These data support previous findings of a subtle negative influence of chemotherapy on cognitive function in a subgroup of breast cancer patients. The results are discussed in terms of the importance of study design. Copyright © 2007 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Stewart, Angela" sort="Stewart, Angela" uniqKey="Stewart A" first="Angela" last="Stewart">Angela Stewart</name></noRegion><name sortKey="Bielajew, Catherine" sort="Bielajew, Catherine" uniqKey="Bielajew C" first="Catherine" last="Bielajew">Catherine Bielajew</name><name sortKey="Collins, Barbara" sort="Collins, Barbara" uniqKey="Collins B" first="Barbara" last="Collins">Barbara Collins</name><name sortKey="Collins, Barbara" sort="Collins, Barbara" uniqKey="Collins B" first="Barbara" last="Collins">Barbara Collins</name><name sortKey="Mackenzie, Joyce" sort="Mackenzie, Joyce" uniqKey="Mackenzie J" first="Joyce" last="Mackenzie">Joyce Mackenzie</name><name sortKey="Tomiak, Eva" sort="Tomiak, Eva" uniqKey="Tomiak E" first="Eva" last="Tomiak">Eva Tomiak</name><name sortKey="Verma, Shailendra" sort="Verma, Shailendra" uniqKey="Verma S" first="Shailendra" last="Verma">Shailendra Verma</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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